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The Cleveland Guardians defeated the Houston Astros 8–5 on April 21 at Progressive Field, with the home team's balanced offensive approach offsetting modest overall production. Cleveland recorded 11 hits and 8 RBIs while drawing 8 walks, though their .231 batting average and .704 OPS reflected inconsistent contact; the Astros countered with 10 hits and a superior .790 OPS but managed only 5 runs, stranding runners in scoring position. Houston's pitching staff surrendered 8 earned runs across 6.05 ERA performance, walking 8 batters and allowing the Guardians to capitalize on free passes. The Astros struck out 7 opposing batters but couldn't overcome their own offensive limitations—no home runs and just 5 RBIs—while Cleveland's single long ball proved enough in a low-power affair. Cleveland's defensive miscue (1 error) didn't prove costly given Houston's inability to convert opportunities. The Guardians' patience at the plate and Houston's control issues suggest the home team's early-season pitching depth may prove more reliable than the Astros' early-April struggles on the mound.