Gijs Brouwer defeated Adrian Mannarino 6–3, 6–4, 6–4 in the first round of the US Open on hard court on 30 August 2022, producing a significant upset against the pre-match favourite. Mannarino, who carried odds of 1.28, was expected to progress comfortably, but Brouwer, at 4.06, executed a dominant performance across all three sets to secure a straight-sets victory. The Dutch player's clinical approach allowed him to maintain control throughout, breaking down Mannarino's resistance with consistent tennis and efficient service games. This result marked a notable scalp for Brouwer in a Grand Slam environment and demonstrated his capacity to trouble seeded opposition on the hard courts of Flushing Meadows.