Jannik Sinner defeated Adrian Mannarino 6–4, 7–6 in the second round of the Cincinnati Masters on hard court on 13 August 2025, confirming his status as the overwhelming pre-match favourite with odds of 1.05 to Mannarino's 14.37. The Italian top seed navigated a competitive encounter against the French left-hander, securing the opening set before edging a tight second-set tiebreak to advance. Sinner's victory maintains momentum in his Cincinnati campaign as he pursues another strong showing at this Masters 1000 event.