Anna Karolina Schmiedlova defeated Agnieszka Radwanska 4–6, 6–3, 6–1 in the second round of the Cincinnati Masters on hard court. The result represented a significant upset, with Radwanska heavily favoured at 1.24 odds against Schmiedlova's 4.61. After dropping the opening set, Schmiedlova seized control in the second and third frames, dismantling the Polish fourth seed with an increasingly dominant display. The Slovak's aggressive baseline game overwhelmed Radwanska's typically precise court positioning and slice-heavy tactics. The comprehensive second-set recovery and commanding third-set performance demonstrated Schmiedlova's capacity to capitalize on opportunities against top-ranked opponents when her aggressive approach finds rhythm on hard courts. The upset marked a notable blemish on Radwanska's Cincinnati campaign and underscored the volatility of Masters 1000 events.