Harmony Tan upset Serena Williams 7-5 1-6 7-6 in the first round of Wimbledon 2022 on grass, a result that defied pre-match odds heavily favouring the 23-time Grand Slam champion. The encounter proved competitive across all three sets, with Tan claiming the opening set before Williams levelled matters decisively in the second. The decider went to a tiebreak, where Tan ultimately prevailed to secure one of the year's most significant upsets. Williams, competing in what would become her final professional tournament, departed the Championships at the earliest stage. Tan's victory marked a career-defining moment for the French player and signalled her emergence as a genuine threat at the sport's highest level.