Marco Cecchinato defeated Pablo Andujar 4–6, 4–6, 6–0, 7–5, 6–0 in the first round of Roland Garros on clay on 24 May 2022, upsetting the pre-match favourite despite entering as the underdog. Andujar controlled the opening sets, securing both through breaks of serve to establish a commanding position. However, Cecchinato mounted a remarkable comeback, dominating the third set without concession before edging a competitive fourth-set tiebreaker. The Italian then sealed victory by claiming the fifth set at love, demonstrating exceptional mental resilience and court awareness to overturn a two-set deficit. The result represents a significant turnaround for Cecchinato, whose ability to recover on clay proved decisive against a seasoned campaigner.