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The Milwaukee Bucks defeated the Washington Wizards 133–120 on October 22 at Fiserv Forum, with Giannis Antetokounmpo leading all scorers with 37 points in a dominant performance. The Bucks shot 51 percent from the field and made 18 three-pointers, establishing early control through a 40-point first quarter before coasting through the middle periods with 32-point second and fourth quarters. Milwaukee's offensive rating of 122.7 proved decisive against Washington's 112.8, while the Bucks' defense held the visitors to 46.9 percent shooting despite the Wizards' 56-rebound advantage. Gary Trent Jr. added 17 points off the bench for Milwaukee, which also distributed 31 assists across the roster. The Wizards, led by Khris Middleton and Paul George with 23 and 21 points respectively, struggled with ball security, committing 13 turnovers to Milwaukee's 8, and could not capitalize on a strong third quarter (37 points) to mount a sustained comeback. The victory signals the Bucks' offensive depth and defensive discipline in the early season.