Alize Cornet defeated Emma Raducanu 6–3, 6–3 in the first round of the 2022 US Open on hard court, a result that upset the pre-match odds in which Raducanu was favoured at 1.74 to Cornet's 2.21. The French veteran's clinical performance saw her dispatch the British third seed with relative ease, controlling both sets and maintaining consistent pressure throughout. Raducanu, the previous year's champion, failed to replicate her 2021 form and appeared unable to find the rhythm required to trouble Cornet's experienced game. The comfortable victory marked a significant setback for Raducanu's title defence and raised questions about her form heading into the latter stages of the season.