Amanda Anisimova defeated Veronika Kudermetova 6–2, 6–2 in the first round of the WTA 250 Charleston event on clay on 1 April 2025, confirming her status as the pre-match favourite with odds of 1.5 to Kudermetova's 2.76. The American's dominant display saw her control both sets with consistent tennis, allowing her opponent minimal opportunities to establish rhythm or momentum. Anisimova's comprehensive victory sets up a favourable platform for her progression through the tournament's early stages.