Bianca Andreescu defeated Petra Martic 6–4, 6–4 in the second round of the Rome Masters on clay on 12 May 2022, confirming her status as pre-match favourite with odds of 1.58. Andreescu's commanding performance against the Croatian opponent reflected her superiority on the surface, as she controlled both sets without requiring a tiebreak. Martic, entering at 2.55 odds, could not sustain the level required to trouble the Canadian on the red clay. The victory underscored Andreescu's growing confidence in Rome and her ability to navigate the tournament's early rounds with authority.