Lorenzo Musetti defeated Flavio Cobolli at the US Open on hard court in the second round, securing a decisive 6–3, 6–2 victory with the match suspended at 2–0 in the third set. As the pre-match favourite with odds of 1.37, Musetti delivered as expected, controlling proceedings from the baseline and breaking Cobolli's serve multiple times to establish commanding leads in both completed sets. Cobolli, the outsider at 3.38, struggled to find rhythm against Musetti's consistency and could not mount a sustained challenge. The Italian's emphatic performance underscores his growing confidence on hard courts and positions him well for a deeper run at Flushing Meadows.