Stéfanos Tsitsipás defeated Jordan Thompson 4–6, 6–4, 6–2 in the second round of the Monte Carlo Masters on clay on 8 April 2025, confirming his status as the heavy pre-match favourite with odds of 1.14 to Thompson's 6.78. After dropping the opening set, Tsitsipás regained control to dominate the final two frames, demonstrating the clinical efficiency expected of the higher-ranked player. The Greek's recovery from a slow start reflects both his experience on the Monte Carlo clay and his ability to adjust tactically mid-match. The result sees Tsitsipás advance to the round of 16 as one of the tournament's top seeds.