Serena Williams defeated Laura Siegemund 6–1, 6–1 in the first round of the Australian Open on hard court on 8 February 2021. Williams, the pre-match favourite at odds of 1.16, delivered a dominant performance to dismiss the German opponent in straight sets. Siegemund, at 6.11 odds, offered little resistance as Williams controlled proceedings throughout the encounter. The comprehensive scoreline underlined Williams's superiority in the early stages of the tournament. The victory marked a commanding start to Williams's campaign at the year's opening Grand Slam.