Novak Djoković defeated Zachary Svajda 6–7, 6–3, 6–3, 6–1 in the first round of the US Open on hard court on 27 August 2025, confirming his heavy pre-match favouritism with odds of 1.09 to Svajda's 9.74. After dropping a tight opening set in a tie-break, Djoković asserted control in the second and third sets, breaking Svajda's resistance with consistent play before closing out the fourth set decisively. The result represents a routine progression for the top seed, though the opening-set loss suggests some early-match rustiness. Djoković advances to the second round seeking to build momentum in his quest for another Grand Slam title.