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The Houston Astros defeated the Minnesota Twins 2–1 on May 19 at Target Field in a low-scoring contest that saw both offenses struggle at the plate. Houston's pitching proved decisive despite a 5.36 ERA, striking out 8 batters while allowing just 5 hits and 1 earned run over the contest. The Astros manufactured their runs efficiently with 5 hits, 1 home run, and 2 RBIs, while Minnesota managed 8 hits but could only convert that into 1 run with a single RBI, striking out 8 times and posting a .709 OPS. The Twins' offense continued a concerning trend of offensive inefficiency, leaving runners stranded despite out-hitting Houston, though their defense remained flawless with no errors. Houston's ability to win despite limited offensive output—just 5 hits and a .248 average—underscores strong pitching execution on the road. The Astros' improved run differential on the road could become a factor in the AL Central race as the season progresses.