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The Minnesota Twins defeated the Houston Astros 4–1 on May 20 at Target Field, with Minnesota's pitching staff dominating behind 15 strikeouts and just five hits allowed. The Twins' offense, while modest with six hits and a .236 batting average, made the most of their opportunities by driving in four runs on two home runs and drawing three walks. Houston's lineup struggled significantly, striking out 15 times while managing only five hits and a single run batted in, with their batters unable to draw a walk in the contest. The Astros' pitching was equally ineffective, surrendering four earned runs across six hits and posting a 5.34 ERA compared to Minnesota's 4.20. This matchup highlighted the Twins' ability to win despite limited offensive production, while Houston's strikeout-heavy approach and poor run prevention suggest continued offensive inconsistency could plague their road trip.