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The St. Louis Cardinals defeated the Houston Astros 9–4 on April 17 at Daikin Park, with the visitors' offense outpacing a Vegas total line of 2 runs. St. Louis capitalized on Houston's pitching struggles, scoring 9 earned runs while allowing just 8 hits and posting a 4.89 ERA. The Cardinals' lineup generated 10 hits and 9 RBIs despite striking out 9 times, posting a .706 OPS that proved sufficient against a depleted Astros rotation. Houston's pitching staff surrendered 9 earned runs across the contest while striking out 9 batters but issuing 4 walks, reflecting control issues that compounded their offensive limitations. The Astros managed just 8 hits and 4 runs, with three home runs providing their only source of power in an otherwise anemic showing. St. Louis's pitching was more efficient, limiting Houston to 8 hits while fanning 10 and walking just 2. This decisive victory suggests the Cardinals' pitching depth may stabilize their early-season run differential, while Houston's rotation concerns will require immediate attention.