Dominic Thiem defeated Alex Molcan 7–6 6–3 in the first round of the ATP 250 event in Buenos Aires on clay on 14 February 2023, confirming his status as pre-match favourite with odds of 1.69 to Molcan's 2.29. Thiem's victory came via a competitive opening set that required a tie-break before he asserted control in the second, breaking serve and consolidating his advantage to secure progression. The Austrian's performance underlined his comfort on the Buenos Aires clay surface and marked a solid start to his campaign in the tournament.