Botic van de Zandschulp defeated Tomas Barrios Vera in the first qualifying round of the 2021 US Open on hard court, winning 6–7, 6–2, 6–2. Van de Zandschulp fought through a competitive opening set that went to a tiebreak before establishing control in the second and third frames to secure his passage through qualifying. The Dutch player's ability to recover after the first-set loss and dominate the closing sets demonstrated sufficient form to advance in the tournament's qualifying draw.