Corentin Moutet defeated Holger Rune 7–5, 5–7, 7–6 in the first round of the Rome Masters on clay on 11 May 2025, securing a significant upset against the pre-match favourite. Rune, seeded higher and backed at odds of 1.2, entered as the clear favourite, whilst Moutet, at 5.02, was positioned as the underdog. The Frenchman's three-set victory showcased composure in a closely contested encounter, particularly in the deciding set, where he edged a tight tiebreak. The result represents a notable scalp for Moutet on the Italian clay and demonstrates his capacity to compete against top-ranked opposition in Masters 1000 events.