Nick Kyrgios defeated Daniil Medvedev 7-6, 3-6, 6-3, 6-2 in the US Open second round on hard court, delivering a significant upset against the tournament favourite. Medvedev entered as the clear pre-match favourite at odds of 1.56 to Kyrgios's 2.6, but the Australian produced a commanding performance to overturn that expectation. After a tight opening set decided in a tie-break, Kyrgios seized momentum in the second, then dominated the third and fourth sets to secure a comfortable victory. The result marked a notable scalp for Kyrgios at Flushing Meadows and represented a disappointing exit for Medvedev, the world number one, who struggled to maintain the consistency required against Kyrgios's aggressive baseline game. Kyrgios advanced to the quarter-finals, while Medvedev's Grand Slam campaign ended prematurely.