Novak Djoković defeated Jan Lennard Struff 6–3, 6–3, 6–2 in the US Open round of 16 on hard court on 31 August 2025, confirming his heavy pre-match favouritism with a commanding display. Struff, the substantial underdog at 5.55 odds, offered little resistance as Djoković controlled the match from start to finish, dropping only seven games across three sets. The Serbian's dominance at Flushing Meadows underscored his continued form at the year's final Grand Slam, positioning him as a formidable threat in the remaining rounds.