Milos Raonic defeated Jordan Thompson 6–2, 6–1 at the Miami Masters, an ATP 1000 event on hard court in the first round on 27 March 2021. The Canadian, who entered as a strong pre-match favourite at odds of 1.23, delivered a dominant performance to dispatch the Australian in straight sets with a decisive scoreline. Thompson, available at 4.73, offered little resistance as Raonic controlled proceedings throughout. The emphatic nature of the victory underscored Raonic's superiority on the day and suggested he would carry momentum into the subsequent rounds of the tournament.