Matteo Berrettini defeated Lloyd Harris 6–4, 7–5 in the Indian Wells Masters R16 on hard court on 15 March 2022. The Italian, who entered as the clear favourite at odds of 1.30 against Harris's 3.92, delivered a composed performance to advance. Berrettini's victory followed the pre-match odds, confirming his status as the stronger player on the day. The two-set win demonstrated controlled tennis from the top seed, who closed out both sets without allowing Harris a significant foothold in either. Berrettini's progression kept alive his campaign at the California Masters.