Thanasi Kokkinakis upset third-round favourite Stéfanos Tsitsipás at the US Open on hard court in the first round, securing a 7–6, 4–6, 6–3, 7–5 victory on 27 August 2024. Tsitsipás entered as the heavy favourite at 1.43 odds, but Kokkinakis, priced at 3.15, proved the steadier competitor across four sets, particularly in the opening tiebreak and the decisive fourth set. The Greek's inconsistency cost him dearly; after levelling the match at one set apiece, he could not maintain momentum as Kokkinakis seized control in the latter stages. The Australian's composure under pressure and ability to close out tight sets proved decisive in a match that demonstrated the unpredictability of early-round Grand Slam tennis. Kokkinakis's upset victory marks a significant scalp and suggests renewed confidence heading into the second round.