Alison Van Uytvanck defeated Venus Williams 6–1, 7–6 in the first round of the US Open on hard court at Flushing Meadows on 30 August 2022. As the pre-match favourite with odds of 1.32, Van Uytvanck delivered a dominant performance, particularly in the opening set, where she broke Williams's serve repeatedly to claim it 6–1. Williams mounted a stronger challenge in the second set, forcing a tie-break, but Van Uytvanck held her nerve to secure the set 7–6 and advance. The result underscored Van Uytvanck's superior form heading into the tournament and marked a significant scalp for the Belgian, who has long sought consistent results at the Grand Slams. Van Uytvanck's commanding display suggests she possesses the firepower to progress deeper into the draw.