Alize Cornet defeated Bianca Andreescu 7–6, 7–5 in the second round of the WTA 250 event in Berlin on grass on 16 June 2021, an upset victory over the pre-match favourite. Andreescu, seeded higher in betting odds at 1.38, entered as the expected winner, but Cornet's composed performance on the grass courts proved decisive. The Frenchwoman secured both sets in tight circumstances, taking the opening set to a tiebreak before converting her advantage in the second frame to advance. The result marked a significant scalp for Cornet and suggested potential momentum heading deeper into the tournament, whilst raising questions about Andreescu's grass-court readiness at this stage of her comeback.