Jessica Pegula defeated Amanda Anisimova 6–2, 7–6 in the Australian Open quarter-final on hard court on 27 January 2026, securing an upset victory despite entering as the underdog at 2.05 odds against Anisimova's 1.76 favourite status. Pegula dominated the opening set with a decisive 6–2 scoreline before the second set proved more competitive, with both players pushing to a tie-break that Pegula ultimately claimed. The result marks a significant advance for Pegula in Melbourne and represents a notable setback for Anisimova's title aspirations at the year's opening Grand Slam.