Amanda Anisimova defeated Maya Joint 7–6, 6–2 at the US Open on hard court in the first round, confirming her status as the pre-match favourite with odds of 1.33 to Joint's 3.6. The American navigated a competitive opening set that went to a tiebreak before asserting control in the second, where she broke clear to secure a comfortable victory. The result marks a solid start for Anisimova in the Grand Slam draw and sets up her progression to the second round.