Aslan Karatsev defeated Nikoloz Basilashvili 6–4, 6–0 in the first round of the ATP 250 Hamburg tournament on clay on 19 July 2022, confirming his status as pre-match favourite with odds of 1.83 to Basilashvili's 2.07. The Russian's dominance was emphatic in the second set, where he conceded just four games to secure a comprehensive victory. Karatsev's commanding performance underscored his growing confidence on the European clay circuit and positioned him favourably for the tournament's later stages.