Lorenzo Musetti defeated Holger Rune 7–5, 3–6, 6–3, 6–2 in the Roland Garros round of 16 on clay, confirming his status as pre-match favourite at odds of 1.49. Rune, who entered at 2.85, competed strongly in the opening set before Musetti's control intensified across the final three sets. The Italian's dominance grew progressively, particularly in the fourth set, where he secured a commanding 6–2 scoreline to advance. Musetti's victory underscores his clay-court credentials and positions him favourably for the quarterfinals at Roland Garros.