Jannik Sinner defeated Mackenzie McDonald 2–6, 6–2, 6–1, 6–2 in the first round of the US Open on hard court on 27 August 2024, as the heavy favourite with odds of 1.02. After dropping the opening set, Sinner dominated the remaining three, progressively tightening his grip on the match as McDonald struggled to find answers. The Italian top seed's recovery and clinical performance in the latter stages underscored his status as a title contender at Flushing Meadows. Sinner advances with momentum intact as he pursues his first Grand Slam title.