David Goffin defeated Adrian Mannarino 6–7, 6–3, 6–2, 7–6 in the first round of the US Open on hard court on 29 August 2024, confirming his status as pre-match favourite. The Belgian recovered from a tight opening set decided in a tiebreak, then dominated the middle frames with consecutive commanding set wins before securing the fourth set in another tiebreak. Goffin's ability to control the second and third sets proved decisive against Mannarino, who could not maintain the intensity required to trouble the favourite across four sets. The victory maintains Goffin's progression through the opening round at Flushing Meadows.