Matteo Berrettini defeated Adrian Mannarino 4–6, 7–5, 7–5 in the first round of the Indian Wells Masters on hard court. Berrettini, the pre-match favourite at 1.43 odds, recovered from losing the opening set to claim a straight-sets victory in terms of match outcome, though requiring three sets overall. Mannarino, despite the longer odds at 2.73, mounted resistance in the second and third sets, each going to 7–5 before Berrettini secured the decisive break. The Italian's composure in the latter stages proved decisive as he turned the match around following an early setback. Berrettini's comeback victory positions him favourably in his Indian Wells campaign.