Marco Cecchinato defeated Alex De Minaur 7–6, 6–4, 6–0 in the first round of Roland Garros on clay on 27 September 2020, confirming his status as the pre-match favourite. De Minaur, positioned as the underdog at 2.27 odds against Cecchinato's 1.71, could not sustain a competitive level throughout the encounter. The Australian took the opening set to a tie-break but lost it, then surrendered the second set before collapsing entirely in the third, winning just four games across the final two sets. Cecchinato's dominant performance, particularly his control on the clay surface, underscored his superiority in this matchup and sets up a second-round meeting with a higher-ranked opponent.