Amanda Anisimova defeated Iga Świątek 6–4, 6–3 in the US Open quarter-final on hard court on 3 September 2025, delivering a significant upset against the pre-match favourite. Świątek entered as the clear favourite at 1.25 odds, whilst Anisimova was priced at 4.4, yet the American produced a composed performance to advance decisively in straight sets. The result represents a notable scalp for Anisimova at Grand Slam level and marks a reversal of recent form for the Polish world number one on a surface traditionally less favourable to her game. Anisimova's progression to the semi-finals underscores her capability on hard courts and raises questions about Świątek's consistency in the latter stages of major tournaments.