Su Wei Hsieh defeated Bianca Andreescu 6-3, 6-2 in the first round of the Australian Open on hard court on 10 February 2021, an upset victory over the pre-match favourite. Andreescu entered as the betting favourite at 1.27 odds, whilst Hsieh was priced at 4.1, yet the Taiwanese player produced a commanding performance to advance comfortably. The decisive margin across both sets underscored Hsieh's control throughout the match, as Andreescu struggled to impose herself on court. The result marked a significant early exit for the Canadian, who had been seeded and expected to progress further in Melbourne. Hsieh's straightforward progression sets up a favourable platform for her second-round challenge.