Botic van de Zandschulp defeated Nick Kyrgios 7–6, 3–0 in the first round of the Indian Wells Masters on hard court on 6 March 2025, confirming his pre-match favourite status with odds of 1.38 to Kyrgios's 3.27. Van de Zandschulp secured a tight opening set via tiebreak before Kyrgios withdrew at 3–0 down in the second, unable to continue. The Dutch player's victory, though aided by Kyrgios's retirement, keeps his Indian Wells campaign on track and maintains his edge in the head-to-head record between the two competitors.