Brandon Nakashima defeated Jesper De Jong 6–2, 6–7, 2–6, 6–2, 7–6 in the first round of the US Open on hard court on 24 August 2025, as expected given his pre-match favourite status at odds of 1.3. De Jong, the underdog at 3.85, mounted a competitive challenge, winning the third set decisively and pushing the American to a deciding fifth set before Nakashima prevailed in the tiebreak. The match saw momentum shift across its five sets, with Nakashima dominating the opening and fourth sets whilst De Jong capitalised on opportunities in the middle stages. Nakashima's comeback from a set down and his composure in the final tiebreak underscore his ability to navigate challenging matches at the Grand Slam level, securing his progression to the second round.