Nick Kyrgios defeated Daniil Medvedev 7-6 6-4 2-6 at the Canada Masters (ATP Masters 1000) on hard court in the second round on 10 August 2022, securing a significant upset victory against the pre-match favourite. Medvedev, who entered as the odds-on favourite at 1.47, could not maintain consistency across the match, losing a competitive opening set in a tiebreak before surrendering the second set and the third in succession. Kyrgios, positioned as the underdog at 2.92, capitalised on his opportunities to claim the win and advance further in the tournament, demonstrating the capacity to trouble top-ranked opponents on hard courts.