Emilio Nava defeated John Millman 7–6, 4–6, 7–6, 1–6, 6–1 in the first round of the US Open on hard court on 29 August 2022, upsetting the pre-match favourite Millman. The American qualifier delivered an uneven performance across five sets, taking the opening tie-break before surrendering the second set. Nava regained control in the third set tie-break, then dominated the final two sets to secure a breakthrough victory at a Grand Slam. The win marked a significant scalp for the young American against an experienced ATP campaigner and suggested he could compete at the highest level despite his qualifier status.