Federico Coria defeated fellow Argentine Francisco Cerundolo 1–6, 6–2, 6–4 in the Round of 16 at the ATP 250 Cordoba event on clay on 24 February 2021, upsetting the pre-match favourite despite entering as the outsider at 2.3 odds. Cerundolo dominated the opening set, breaking serve decisively to establish control, but Coria regrouped substantially in the second and third frames, reversing momentum through improved consistency and court positioning. The comeback victory saw Coria advance to the quarter-finals on home soil, a significant result that demonstrated his capacity to recover from early adversity against a seeded opponent. The result enhances Coria's credentials on the South American clay circuit.