Ons Jabeur defeated Madison Brengle 7–5, 6–2 at the US Open on hard court in the first round on 29 August 2022, confirming her status as the heavy pre-match favourite. Jabeur, seeded and priced at 1.16, controlled the encounter despite Brengle's competitive opening set, which went to 7–5 before the Tunisian accelerated in the second frame to seal victory in straight sets. The result underscored Jabeur's credentials as a genuine contender on the American hard courts and sent her through to the next round with relative comfort.