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The Milwaukee Brewers dominated the San Diego Padres 6–1 on March 21 at American Family Fields of Phoenix, delivering a decisive spring training victory. Milwaukee's offense proved efficient despite modest volume, collecting 8 hits and 3 home runs while driving in all 6 runs with a .799 OPS. The Brewers' pitching staff was the game's defining factor, striking out 10 Padres batters while limiting San Diego to just 6 hits and 1 earned run over the contest. San Diego's lineup struggled to generate offense, striking out 10 times and managing only 1 RBI despite a respectable .829 OPS that reflected some power potential with 1 home run. Milwaukee's pitchers walked just 3 batters while posting a 4.83 ERA, controlling the game from start to finish. The Padres' pitching allowed 5 earned runs and 8 hits, indicating continued work needed before the regular season. This lopsided result suggests Milwaukee's arms are further along in spring preparation than San Diego's rotation.