Thanasi Kokkinakis defeated Aleksandar Vukic 6–7, 6–3, 6–2 in the Adelaide ATP 250 quarter-final on hard court, confirming his status as the pre-match favourite with odds of 1.51 to Vukic's 2.77. After dropping a tight opening set in a tie-break, Kokkinakis dominated the subsequent two sets to secure a commanding victory. The Australian's composed performance in the latter stages demonstrated his ability to control rallies and apply pressure when it mattered. Kokkinakis's progression to the semi-finals strengthens his position in the tournament and continues his solid start to the 2022 season.