Daniil Medvedev defeated Alex De Minaur 6–4, 6–4 in the Shanghai Masters quarter-final on hard court on 10 October 2025, producing a significant upset against the pre-match favourite. De Minaur entered as the odds-on favourite at 1.56, whilst Medvedev was priced at 2.6, yet the Russian controlled both sets with consistent play to advance in straight sets. The result represents a notable reversal of form between the two players and strengthens Medvedev's position in the latter stages of the Masters 1000 event. Medvedev now progresses to the semi-finals with momentum, whilst De Minaur's campaign at Shanghai concludes at the quarter-final stage.