Alex Molcan defeated Karen Khachanov 6–2, 7–6 in the second round of the ATP 250 event in Lyon on clay on 19 May 2022, an upset victory against the pre-match favourite. Khachanov entered as the odds-on favourite at 1.56, whilst Molcan was priced at 2.59, yet the Slovak produced a dominant first set and held firm in a competitive second-set tiebreak to secure his passage. The result represents a significant scalp for Molcan and suggests improved form on the clay-court season ahead of the French Open.