Holger Rune defeated Alexandre Muller 6–2, 6–4 in the first round of the Canada Masters on hard court on 31 July 2025, confirming his status as pre-match favourite with odds of 1.27 to Muller's 4.17. The Danish player controlled proceedings throughout, breaking Muller's serve consistently to secure both sets with relative comfort. Rune's dominant performance underscored his credentials heading into the latter stages of the Masters 1000 event, whilst Muller's early exit leaves him with work to do in the remainder of the season.