Amanda Anisimova defeated Elisabetta Cocciaretto 6–3, 6–3 in the first round of the Rome Masters on clay on 13 May 2019. As the heavy favourite with odds of 1.06, Anisimova delivered a dominant performance against the Italian qualifier, who started at 11.59. The American's convincing straight-sets victory reflected her status as the expected winner and underlined her credentials on the clay-court circuit. The result kept Anisimova on track in the tournament.