Amanda Anisimova defeated Katrina Scott 4–6, 6–4, 6–1 in the first round of the US Open on hard court on 3 September 2020, confirming her status as the heavy favourite at odds of 1.13 to Scott's 7.11. After dropping the opening set, Anisimova regrouped to claim the next two in succession, securing a commanding third-set performance that underscored her superiority over the qualifier. The victory represented a routine progression for the American into the second round of the year's final Grand Slam.